If you think you know what you're getting with this show, you're probably wrong. In the best possible way.
I was not expecting Keanu Reeves and the mannerisms and catch phrases from "Keanu" I think really set the tone for this mash up. Set in the midst of WWII, an increasingly drunk Orson Wells and the crew at Dayton Dayco Radio Hour create a visually fun spectacle in the retelling of the tale.
I think it would have been funnier if it was a trolly unable to go more than 15 mph (with a running gag of people mistakenly hearing 50 mph) to keep within the 1940's theme, but perhaps keeping it as a bus at 50 is a subtle hint at the "absurdisms" you're about to encounter.
I think the acting was incredibly strong and each played up their mannerisms authentic to the period (except Keanu who clearly is not in the 40's) with perfection.
I also found it funny to keep emphasizing the American Way when Keanu is Canadian. Not sure if that was intentional, but it was a bit of a high brow comedy nod that made me laugh.
This may not be as fun a ride if you've not seen the original source material, but that is just speculation.